Pair Name | Caffeic acid phenethyl ester, Bortezomib | ||
Phytochemical Name | Caffeic acid phenethyl ester (PubChem CID: 5281787 ) | ||
Anticancer drug Name | Bortezomib (PubChem CID: 387447 ) | ||
Structure of Phytochemical |
Download
2D
MOL
3D
MOL
|
||
Structure of Anticancer Drug |
Download
2D
MOL
3D
MOL
|
Pair Name | Caffeic acid phenethyl ester, Bortezomib | |||
Disease Info | [ICD-11: 2A83] | Multiple myeloma | Investigative | |
Gene Regulation | Down-regulation | Expression | IL6 | hsa3569 |
Down-regulation | Activity | NFKB1 | hsa4790 | |
In Vitro Model | ARH-77 | Plasma cell myeloma | Homo sapiens (Human) | CVCL_1072 |
In Vivo Model | Female BALB/c mice (5–6 weeks old) were use in this study. | |||
Result | We think that our study, which is the first to demonstrate the in vitro and in vivo effectiveness of the.combined use of CAPE and bortezomib, will be a pioneer for future human applications of CAPE in MM. |
No. | Title | Href |
---|---|---|
1 | An in vitro and in vivo investigation of the cytotoxic effects of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester and bortezomib in multiple myeloma cells. Turk J Med Sci. 2015;45(1):38-46. doi: 10.3906/sag-1401-127. | Click |